林海双，男，中国科学技术大学苏州高等研究院副研究员，主要从事利用基因密码子扩展技术对蛋白的定点修饰，从而调控干细胞/类器官发育分化及无义突变疾病治疗研究；利用CRISPR/Cas9和Prime editing等基因编辑技术构建类器官体外疾病模型，并研究疾病的发病机理和进行药物筛选研究。目前共发表SCI论文36篇，其中以第一/共一作者在Theranostics，Biomaterials, Advanced Healthcare Materials，Biofabrication, Stem Cell Reports等杂志公开发表SCI论文18篇；谷歌学术总引用1404次， H-index 为22。担任AJBLS, Scientific Reports等期刊审稿人，及JoVE杂志的Invited Guest editor。
工作经历
2023/11-至今，中国科大苏州高等研究院，特任副研究员
2019/08-2022/08，北京大学，助理研究员
2015/01-2018/12，University of Nebraska-Lincoln (USA)，Postdoc
学习经历
2011/09-2014/07，北京协和医学院
2008/09-2011/07，大连医科大学
2004/09-2008/07，华北煤炭医学院
电子邮箱
hlin9@ustc.edu.cn
主要学术论文
1.中国科学技术大学苏州高等研究院引进人才启动经费，50万元，2023-2026。
2. BMU2020JC005，基础研究项目，医学科学部/药物学/生物技术药物, RNA病毒感染类脑器官的模型研究，80万元，2021-01-01 至 2022-12-31，参与。
3. 2018ZX09J18114，生物防御型复制缺陷病毒疫苗的快速制备关键技术研究，1137万元，2018-2021，参与研究和结题。
4.2018ZX09711003-001-003，基于细胞工厂的PTC 技术和类人脑及肺微型器官仿生系统的建立，459万，2018-2021，参与研究和结题。
5. NIH R33, A single Conical Tube Device for Precision CAR-T Cells Manufacturing, 129万美元，2018-2021（5/5）。
6. Nebraska DHHS Stem Cell Research Grant, A Method for Culturing Induced Pluripotent Stem Cells, 11万美元，2017-2018（4/4）。
7. Nebraska DHHS Stem Cell Research Grant, Purification and Proliferation of Mouse Spermatogonia Stem Cells, 11万美元，2016-2017（3/4）。
8. Nebraska DHHS Stem Cell Research Grant, Novel Stem Cell Therapy for Parkinson’s Disease, 8.7万美元，2016-2017（2/3）
获奖及荣誉情况
若干微小RNA 和蛋白基因在髓系生产和白血病中的功能和机制研究，教育部高等学校自然科学奖二等奖，2018
主要学术论文
1. Xiaodong Zhang†, Haishuang Lin†✉, Liangzhen Dong†, Qing Xia✉. Recapitulating Influenza Virus Infection and Facilitating Antiviral and Neuroprotective Screening in Tractable Brain Organoids. Theranostics. 2022 Jul 7;12(12):5317-5329. (IF: 11.6，SCI-1区).
2. Haishuang Lin, Qiang Li, Qian Du, Ou Wang, Zhanqi Wang, Leonard Akert, Mark A. Carlson, Chi Zhang, Anuradha Subramanian, Chi Zhang, Matthew Lunning, Ming Li, Yuguo Lei✉. Integrated generation of induced pluripotent stem cells in a low-cost device. Biomaterials. 2019 Jan;189: 23-36. (IF: 15.304, SCI-1区) .
3. Haishuang Lin*, Qian Du*, Qiang Li, Ou Wang, Zhanqi Wang, Neety Sahu, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. Hydrogel-based bioprocess for scalable manufacturing of human pluripotent stem cells-derived neural stem cells. ACS Applied Materials & Interfaces. 2018 Sep 5;10(35):29238-29250. (IF: 10.383, SCI-1区).
4. Haishuang Lin*, Qiang Li*, Ou wang, Jack Rauch, Braden Harm, Hendrik J. Viljoen, Chi Zhang, Erika Van Wyk, Chi Zhang, Yuguo Lei✉. Automated Expansion of Primary Human T Cells in Scalable and Cell-Friendly Hydrogel Microtubes for Adoptive Immunotherapy. Advanced Healthcare Materials. 2018 Aug;7(15): e1701297. (IF: 11.092, SCI-1区).
5. Haishuang Lin*, Qiang Li*, Yuguo Lei✉, Three-dimensional tissues using human pluripotent stem cell spheroids as biofabrication building blocks. Biofabrication. 2017 Apr 24;9(2):025007. (Highlights of 2017. IF: 11.061, SCI-1区).
6. Jia-Nan Gong*, Jia Yu*, Hai-Shuang Lin*, Xin-Hua Zhang, Xiao-Lin Yin, Zhen Xiao, Fang Wang, Xiao-Shuang Wang, Rui Su, Chao Shen, Hua-Lu Zhao, Yan-Ni Ma, Jun-Wu Zhang✉. The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia. Cell Death and Differentiation. 2014 Jan;21(1):100-112. (IF: 12.067, SCI-1区).
7. Ningning Shi#, Le Tong#, Haishuang Lin#✉, Zhetao Zheng, Haoran Zhang, Liangzhen Dong, Yuelin Yang, Yuxuan Shen, Qing Xia✉. Optimizing eRF1 to enable the genetic encoding of three distinct Non-canonical amino acids in mammalian cells. Advanced Biology (Weinh). 2022 Jul 11; e2200092. (IF: 4.053, SCI-1区).
8. Zhujun Jiang†, Haishuang Lin†, Haoran Zhang†, Ningning Shi†, Zhetao Zheng, Liangzhen Dong, Yuelin Yang, Qing Xia✉. An Integrative Analysis of the Immune features of Inactivated SARS-CoV-2 Vaccine (CoronaVac). Vaccines. 2022 May 30;10(6):878. (IF: 4.961, SCI-2区).
9. Xuesheng Wu†, Zhetao Zheng†, Hongmin Chen†, Haishuang Lin†, Yuelin Yang, Yachao Bai, Qing Xia✉. Sterilization of drug-resistant influenza virus through genetic interference inspired by unnatural amino acid-engineered particles. Advanced Therapeutics. 2022. 5,2200069. (Cover article， IF: 5.003, SCI-1区).
10. Qing Liu*, Zhen Liu*, Hongyu Gu*, Yuxia Ge*, Xusheng Wu*, Fuxing Zuo*, Qian Du, Yuguo Lei✉, Zhanqi Wang✉, Haishuang Lin✉. Comparative Study of Differentiating Human Pluripotent Stem Cells into Vascular Smooth Muscle Cells in Hydrogel-based Culture Methods. Regenerative Therapy, 2022 Dec 21;22:39-49.（IF:3.651）
11. Zhanqi Wang*, Fuxing Zuo*, Qing Liu*, Xusheng Wu*, Qian Du, Yuguo Lei✉, Zhangmin Wu✉, Haishuang Lin✉. Comparative Study of Human Pluripotent Stem Cell-Derived Endothelial Cells in Hydrogel-Based Culture Systems. ACS Omega. 2021 Mar 2;6(10):6942-6952. (IF: 4.132，SCI-3区)
12. Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. Manufacturing Human Pluripotent Stem Cells Derived Endothelial Cells in Scalable and Cell-friendly Microenvironments. Biomaterials Science. 2018 Dec 18;7(1):373-388. (IF: 7.59, SCI-2区)
13. Haishuang Lin*, Xuefeng Qiu*, Qian Du, Qiang Li, Ou Wang, Leonard Akert, Zhanqi Wang, Dirk Anderson, Kan Liu, Linxia Gu, Chi Zhang, Yuguo Lei✉. Engineered Microenvironment for Manufacturing Human Pluripotent Stem Cells Derived Vascular Smooth Muscle Cells. Stem Cell Reports. 2019 Jan 8;12(1):84-97. (IF: 7.294, SCI-1区).
14. Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Zhanqi Wang, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. Differentiating human pluripotent stem cells into vascular smooth muscle cells in three dimensional thermoreversible hydrogel. Biomaterials Science. 2018 Dec 18;7(1):347-361. (IF: 7.59, SCI-2区)
15. Haishuang Lin, Qian Du, Qiang Li, Ou Wang, Christian Elowsky, Kan Liu, Chi Zhang, Soonkyu Chung, Bin Duan, Yuguo Lei✉. A Scalable and Efficient Bioprocess for Manufacturing Human Pluripotent Stem Cells-Derived Endothelial Cells. Stem Cell Reports. 2018 Aug 14;11(2):454-469. (IF: 7.294, SCI-1区)
16. Haishuang Lin, Qiang Li, Yuguo Lei✉. An Integrated Miniature Bioprocessing for Personalized Human Induced Pluripotent Stem Cell Expansion and Differentiation into Neural Stem Cells. Scientific Reports. 2017 Jan 6; 7:40191. (IF: 4.996, SCI-3区)
17. Qiang Li*, Haishuang Lin*, Ou Wang, Xuefeng Qiu, Srivatsan Kidambi, Loic P. Deleyrolle, Brent A. Reynolds, Yuguo Lei✉. Scalable Production of Glioblastoma Tumor initiating Cells in 3 Dimension Thermoreversible Hydrogels. Scientific Reports. 2016 Aug 23; 6:31915. (IF: 4.996, SCI-3区)
18. Hai-Shuang Lin, Jia-Nan Gong, Rui Su, Ming-Tai Chen, Li Song, Chao-Shen, Fang Wang, Yan-Ni Ma, Hua-Lu Zhao, Jia Yu, Wei-Wei Li, Li-Xia Huang, Xin-Hua Xu, Jun-Wu Zhang✉. miR-199a-5p inhibits monocyte/macrophage differentiation by targeting the activin A type 1B receptor gene and finally reducing C/EBP alpha expression. Journal of Leukocyte Biology. 2014 Dec; 96 (6):1023-1035. (IF: 6.011, SCI-2区)
