吴田宏，中国科学技术大学苏州高等研究院博后，主要从事生物正交化学在近红外二区有机荧光染料设计及药物递送载体构建中的应用研究，合作导师为刘世勇教授、胡祥龙研究员。
工作经历
2024/01-至今，中国科大苏州高等研究院，博后
学习经历
2019/09-2023/12，西安交通大学，博士
2015/09-2018/12，山东师范大学，硕士
2011/09-2015/06，山东师范大学，学士
电子邮箱
thwu@ustc.edu.cn
主要科研项目
1. 2024年国家自然科学基金青年基金，22405266，生物正交反应激活型NIR-Ⅱ荧光染料开发及活体成像应用研究，2025.1-2027.12，30万，主持，在研；
2. 中国博士后科学基金第75批面上项目，2024M753146，四嗪生物正交激活的NIR-Ⅱ荧光染料开发及精准成像研究，2024.7-2026.6，8万，主持，在研；
3. 2024年江苏省自然科学基金青年基金，BK20240465，生物正交激活NIR-II荧光的肿瘤药物靶向递送体系构建及精准诊疗研究，2024.9-2027.8，20万，主持，在研。
获奖及荣誉情况
1. 入选2024年江苏省卓越博士后计划
2. 西安交通大学优秀研究生、优秀毕业生
主要学术论文
1. Wu T., Zhang H., Zhang P., James T., Sun X.* A Rationally Designed Prodrug for the Fluorogenic Labeling of Albumin and Theranostic Effects on Drug-Induced Liver Injury, Analytical Chemistry, 2024, 96(8): 3498-3507;
2. Wu T., Huang S., Feng X., Liu X., James T. D., Sun X.,* Qian X. Visualizing Drug Release from a Stimuli-Responsive Soft, Material Based on Amine–Thiol Displacement, ACS Applied Materials & Interfaces, 2023, 15(19): 22967-22976;
3. Wu T., Bian W., Wang C., Qiu J., Sun X.* A Ring‐Controlled Fluorescent Platform for Visualizing Polymer Degradation, Aggregate, 2022, 4(3), e294;
4. Wu T.,# Feng X.,# Sun X.* Chemically Triggered Soft Material Macroscopic Degradation and Fluorescence Detection Using Self-propagating Thiol-Initiated Cascades, Polymer Chemistry, 2022, 13(7): 922-928;
5. Wu T.,# Liang T.,# Hu W.,# Du M., Zhang S., Zhang Y., Anslyn E. V.,* Sun X.* Chemically Triggered Click and Declick Reactions: Application in Synthesis and Degradation of Thermosetting Plastics, ACS Macro Letters, 2021, 10(9): 1125-1131;
6. Xie X.,#Wu T.,# Wang X.,* Li Y., Wang K., Zhao Z., Jiao X. and Tang B.* A Two-photon Fluorescent Probe for Ratiometric Visualization of Hypochlorous Acid in Live Cells and Animals Based on A Selenide Oxidation/Elimination Tandem Reaction. Chemical Communications, 2018, 54, 11965-11968;
7. Feng X., Wu T., Sun X.,* Qian X., “Indanonalkene” Photoluminescence Platform: Application in Real-Time Tracking the Synthesis, Remodeling and Degradation of Soft Materials. Journal of the American Chemical Society, 2021, 51, 21622-21629;
8. Zhang P., Wu T., Cao H., Zhang J.,* James T. D.,* Sun X.* Fluorescence Detection of Volatile Amines Using an Indanonalkene Platform. Organic Chemistry Frontiers, 2023. 10, 1393-1398;
9. Sedgwick A., Brewser J. T., Wu T., Feng X., Bull D. B., Qian X. Sessler J. L.,* James T. D.,* Anslyn E. V.,* and Sun X.* Indicator Displacement Assays (IDAs): The Past, Present and Future. Chemical Society Review, 2021, 50, 9-38.
