张延好，中国科学技术大学苏州高等研究院博后，专注于小核酸药物递送载体LNP中关键组分可电离脂质的研发，力求开发出适用于不同器官疾病的多种脂质库。合作导师为刘世勇教授与胡祥龙研究员。

工作经历

2024/04-至今，中国科大苏州高等研究院，博后

学习经历

2020/03-2024/3，东南大学，博士

2016/09-2019/06，安徽大学，硕士

2012/09-2016/06，皖西学院，学士

电子邮箱

yhzhangr@ustc.edu.cn

主要科研项目

江苏省科技项目，BE2022826，基因药物载体脂质纳米粒核心关键技术与应用研究，2022.7-2025.6，100万，在研，参与。

获奖及荣誉情况

1. 入选2024年江苏省卓越博士后计划

2. 安徽省优秀毕业生（2016）

主要学术论文

1. Zhang Y,; Wang J,; Xing H,; Liu C,; Zha W,; Dong S,; Jiang Y,; and Li X*. Enhanced immunogenicity induced by mRNA vaccines with various lipid nanoparticles as carriers for SARS-CoV-2 infection. Journal of Materials Chemistry B. 2023, 11, 7454-7465.

2. Jiang Y,;† Zhang Y,;† Liu C,; Liu J,; Xue W,; Wang Z,; Li X*. Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy. Journal of controlled release. 2024, 368, 663-675.

3. Zhang Y.; Wang J,; Liu C,; Xing H,; Jiang Y,; and Li X*. Novel disulfide bond bridged 7-ethyl-10-hydroxyl camptothecin-undecanoic acid conjugate/human serum albumin nanoparticles for breast cancer therapy. Journal of Materials Chemistry B. 2023, 11, 2478-2489.

4. Zhang Y,; Wang J,; Xing H,; Liu C,; and Li X*. Redox-responsive paclitaxel-pentadecanoic acid conjugate encapsulated human serum albumin nanoparticles for cancer therapy. International Journal of Pharmaceutics. 2023, 635, 122761.

5. Zhang Y,; Zhang H,; Wang J,; Liu C,; Xing H,; Jiang Y,; and Li X*. Reduction-Responsive Docetaxel Prodrug Encapsulated within Human Serum Albumin Nanoparticles for Cancer Therapy. Molecular Pharmaceutics. 2023, 20, 5, 2513–2526.

6. Liu J,;† Zhang Y,;† Liu C,; Jiang Y,; Wang Z,; and Li X*. Paclitaxel prodrug-encapsulated poly(ethylene glycol)-b-polypeptide micelles with redox/pH dual responsiveness for cancer chemotherapy. International Journal of Pharmaceutics. 2023, 123398 .

7. Liu J,; Zhang Y,; Liu C,; Jiang Y,; Wang Z,; Guo Z*,; and Li X*.A single dose of VEGF-A circular RNA sustains in situ long-term expression of protein to accelerate diabetic wound healing. Journal of controlled release. 2024, 373, 319-335 .

8. Zhang Y,; Li l*,; Nie K,; and Zheng S*.Thermomechanical, surface and shape memory properties of thermosetting blends of epoxy with Poly(ethylene oxide): An impact of POSS microdomain formation. Materials Chemistry and Physics. 2020, 24, 122183

9. Zhang Y,; Zhao B.; Li l,; Nie K*,; and Zheng S*. Polyhedral oligomeric silsesquioxane-capped poly(N-vinyl pyrrolidone) amphiphiles: synthesis, self-assembly, and use as porogen of nanoporous poly(vinylidene fluoride). Colloid and Polymer Science. 2019, 297, 141–153.

10. Wang J.; Zhang Y.; Dong S.; Zha W.; Liu, C.; Wang Y.; Jiang Y.; Xing H.; Li X*. Bivalent mRNA vaccines against three SARS-CoV-2 variants mediated by new ionizable

lipid nanoparticles. International Journal of Pharmaceutics. 2023, 7, 123155.

11. Wang J.; Zhang Y.; Liu C.; Zha W.; Dong S.; Xing H.; Li X*. Multifunctional lipid nanoparticles for protein kinase N3 ShRNA delivery and prostate cancer therapy.

Molecular Pharmaceutics. 2022, 19, 12, 4588–4600.

12. Wang J.; Zhang Y.; Liu C.; Zha W.; Dong S.; Wang Y.; Jiang Y.; Xing H.; Li X*. Trivalent mRNA Vaccine against SARS-CoV-2 and Variants with Effective Immunization.

Molecular Pharmaceutics. 2023, 20, 10, 4971–4983.

专利

[1] 李新松，张延好，刘锦宇，姜宇豪，王梓豪，一种可离子化脂质或其药学上可接受

的盐、组合物及应用，CN 116836074 A。

[2] 李新松，张延好，姜宇豪，王吉，一种可离子化脂质或其药学上可接受的盐、组合

物和应用，CN 117003659 A。

[3] 李新松，刘锦宇，张延好，姜宇豪，一种可离子化脂质或其药学上可接受的盐、组

合物和应用，CN117645549A。

[4] 李新松，王吉，张延好，刘超，邢寒磊，董硕，查文慧，一种可离子化脂质、其组

合物及应用，CN114907243B。

[5] 李新松，邢寒磊，张延好，聚合物载体及其载药胶束和药物组合物，CN 116370410 A。