邓志杰博士，中国科学技术大学苏州高等研究院/生物医学工程学院特任教授，博士生导师，于2025年入选“国家级海外高层次青年人才项目”。2020年在南开大学元素有机化学国家重点实验室获得博士学位，师从汤平平教授；随后赴美国纽约西奈山医学院从事药物化学博士后研究，合作导师为Jian Jin教授。长期致力于小分子靶向创新药物的研发，相关成果发表于《Nature Communication》、《Journal of the American Chemical Society》、《Angewandte Chemie International Edition》、《Journal of Medicinal Chemistry》等国际知名期刊，并已申请PCT国际专利。
课题组热忱欢迎具有有机化学、药物化学、细胞生物学、分子生物学、化学生物学、生物医学工程、医学、药学等相关背景的优秀青年学者和学生加盟。现面向海内外招聘副研究员、博士后，同时招收博士及硕士研究生，诚邀对靶向创新药物研发及生物医学工程等方向感兴趣的有志之士申请加入。
电子邮箱
研究方向
1.利用人工智能(AI)辅助药物设计及高通量筛选技术，开发结构新颖的小分子药物，并开展系统的成药性优化研究。
2.聚焦靶向蛋白降解(PROTAC)和分子胶药物研发，探索针对“难成药”靶点的降解策略；并发展新型双功能分子药物，用于靶向癌症治疗。
3.致力于抗体偶联药物的开发与优化，推动新型偶联技术及连接子-毒素组合的设计与应用。
科研项目
2025年国家级海外高层次青年人才项目
主要学术论文（#共同一作，*通讯作者）
(1)Deng, Z#.; Chen, L#.; Qian, C#.; Liu, J#.; Wu, Q#.; Song, X#.; Xiong, Y#.; Wang, Z.; Hu, X.; Inuzuka, H.; Wei, W*.; Jin, J*. The First‐In‐Class Deubiquitinase‐Targeting Chimera Stabilizes and Activates cGAS.Angewandte Chemie International Edition2025, 64, e202415168.
(2)Deng, Z#; Catlett, J#; Lee, Y#; Wu, Q; Xu, Z; Xie, L; Chen, X; Xiong, Y; Kaniskan, H*; Jin, J*. Harnessing the SPOP E3 Ubiquitin Ligase via Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation.Journal of Medicinal Chemistry2025,68,8634−8647.
(3)Deng, Z#.; Meng, L#.; Bing, X.; Niu, S.; Zhang, X.; Peng, J.; Luan, Y.-X.; Chen, L.; Tang, P*. Silver-Enabled Dearomative Trifluoromethoxylation of Indoles.Journal of the American Chemical Society2024,146 (4), 2325-2332.
(4)Deng, Z.; Zhao, M.; Wang, F.; Tang, P*. Selective C-H trifluoromethoxylation of (hetero) arenes as limiting reagent.Nature Communications2020,11 (1), 2569.
(5) Chen, L#.;Deng, Z#.; Xiong, Y#.; Liu, J#.; Huang, D.; Wang, J.; Chen, Y.; Inuzuka, H.; Xie, L.; Chen, X.; Jin, J*.; Wei, W*. Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy.Journal of the American Chemical Society2025,147 (33), 29875-29883.
(6)Kabir M#.; Kim Y#.;Deng, Z#.;Xiang Y#.; Sargunas P.; Wang Z.;Jin, J*.; Shi, Y*. Multispecific nanobody degraders co-deplete membrane receptors and enable targeted delivery of diverse payloads.Nature Communications2026, (Accepted).
(7) Kim, Y#.; Gumpper, R. H#.; Liu, Y#.; Kocak, D. D.; Xiong, Y.; Cao, C.;Deng, Z.; Krumm, B. E.; Jain, M. K.; Zhang, S.; Jin, J.; Roth, B. L*. Bitter taste receptor activation by cholesterol and an intracellular tastant.Nature2024, 1-8.
(8) Hosseini, A#.; Qiu, X#.; Xiong, Y.; Chiang, K. H. N.; Catlett, J.; Kaltheuner, I.; Deng, Z.; Shi, Y*.; Jin, J*. Discovery of an LSD1 PROTAC degrader.PNAS,2025, 122 (20), e2425812122.
(9) Guo, L.; Fang, R.; Liu, Y.; Zhao, Z.; Ye, N.;Deng, Z.; Altafa, M.; Tang, P*. Silver-mediated intermolecular ortho-trifluoromethoxylation of pyridyl-arenes.Organic & Biomolecular Chemistry2025,23, 9336-9340.
(10) Velez, J#.; Han, Y#.; Yim, H.; Yang, P.;Deng, Z.; Park, K.-s.; Kabir, M.; Kaniskan, H. U. m.; Xiong, Y*.; Jin, J*. Discovery of the First-in-class G9a/GLP PROTAC Degrader.Journal of Medicinal Chemistry2024,67 (8), 6397-6409.
(11) Li, Y.; Gao, Y.;Deng, Z.; Cao, Y.; Wang, T.; Wang, Y.; Zhang, C.; Yuan, M.; Xie, W*. Visible-light-driven reversible shuttle vicinal dihalogenation using lead halide perovskite quantum dot catalysts.Nature Communications2023,14 (1), 4673.
(12) Singh, I#.; Li, F#.; Fink, E. A#.; Chau, I.; Li, A.; Rodriguez-Hernandez, A.; Glenn, I.; Zapatero-Belinchon, F. J.; Rodriguez, M. L.; Devkota, K.;Deng, Z.; White, K.; Wan, X.; Tolmachova, N. A.; Moroz, Y. S.; Kaniskan, H. U.; Ott, M.; Garcia-Sastre, A.; Jin, J.; Fujimori, D. G.; Irwin, J. J*.; Vedadi, M*.; Shoichet, B. K*. Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.Journal of Medicinal Chemistry2023,66 (12), 7785-7803.
(13) Li, Y.; Wang, T.; Wang, Y.;Deng, Z.; Zhang, L.; Zhu, A.; Huang, Y.; Zhang, C.; Yuan, M.; Xie, W*. Tunable photocatalytic two-electron shuttle between paired redox sites on halide perovskite nanocrystals.ACS Catalysis2022,12 (10), 5903-5910.
(14) Jiang, X.;Deng, Z.; Tang, P*. Direct dehydroxytrifluoromethoxylation of alcohols.Angewandte Chemie International Edition2018,130 (1), 298-301.
(15) Teng, Y#.; Li, X.; Yang, K.; Li, X.; Zhang, Z.; Wang, L.;Deng, Z.; Song, B.; Yan, Z.; Zhang, Y.; Lu, K*.; Yu, P*. Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers.European Journal of Medicinal Chemistry2017,125, 335-345.
(16) Lu, K.;Deng, Z.; Li, M.; Li, T.; Zhao, X*. Transition metal-free direct trifluoromethylthiolation of indoles using trifluoromethanesulfonyl chloride in the presence of triphenylphosphine.Organic & Biomolecular Chemistry2017,15 (5), 1254-1260.
(17) Zhao, X.;Deng, Z.; Wei, A.; Li, B.; Lu, K*. Iodine-catalysed regioselective thiolation of flavonoids using sulfonyl hydrazides as sulfenylation reagents.Organic & Biomolecular Chemistry2016,14 (30), 7304-7312.
专利发明
1.Manish, J.; SLOCUM, S.; SKINIOTIS, G.; BARROS, X.; Jin, J.; KANISKAN, H. U.; Sun, N.; Rehong, S.; Xiong, Y.; Yudao, S.; Zhongli, X.; Xing, Qiu.; Chao, Qian.; Xiangyang Song.;Zhijie Deng.; Bryan Roth.; Diberto Jeffrey.; Kualae Kim.; Suomivuori Carl-Mikael.; Daemgen Marc A.; Dror Ron.; Shoichet Brian.; Kaplan Anat Levit. Heterocyclic compounds as 5ht2a biased agonists, 2022-12-16, WIPO,PCT/US2022/053168.
2.Jian Jin.; Wenyi Wei.; Yan Xiong.; Xiangyang Song.; Qiong Wu.; Chao Qian.;Zhijie Deng.; Jing Liu.; Xufen YU. Otub1 small-molecule binders and otub1-recruiting deubiquitinase-targeting chimeras (dubtacs), 2024-04-19, WIPO,PCT/US2024/025509.
