梁亭西子，中国科学技术大学生物医学工程学院/化学与材料科学学院特任研究员，入选中科院人才计划青年项目 (B类)。主要从事药物递释系统研究，聚焦功能性医用材料，通过化学合成策略、材料精密构筑与生物医学需求深度融合，创新性构建了多种功能材料体系: 1）生物分子凝聚体药物储库；2）抗癌新材料-细胞器脂滴；3）协同疾病微环境调控的纳米框架，突破传统递药系统在时空控制、病灶靶向及生物安全性等方面的技术瓶颈，在智能可控药物递释、癌症治疗等领域取得突破。以第一作者身份在Nature Biomedical Engineering（封面文章）、Advanced Materials（封面文章）及Angewandte Chemie International Edition等国际高水平期刊发表论文9篇，以合著者身份发表论文13篇。申请国际发明专利2项。获中国博士后科学基金面上项目一等资助，参与国家自然科学基金委员会重点项目及面上项目4项。担任Nano Research等SCI期刊独立审稿人。
工作经历
2025/07-至今，中国科学技术大学苏州高等研究院，特任研究员
2021/07-2024/12，浙江大学药学院，博士后（合作导师：顾臻教授）
学习经历
2015/09-2021/06，南京大学化学化工学院，博士（导师：朱俊杰/姜立萍教授）
2019/02-2020/05，美国加州大学洛杉矶分校，联合培养博士生（导师：顾臻教授）
2011/09-2015/06，武汉大学化学与分子科学学院，学士
电子邮箱
lingtingxizi@ustc.edu.cn
研究方向
1. 液液相分离凝聚体的生物医药应用
2. 脂质代谢调控在不同病理微环境中的作用，探索癌症、肥胖等脂质代谢异常疾病的干预措施。
3. 新型生物材料研发，结合丰富多样生理现象与分子机制，探索疾病诊疗新方法
获奖及荣誉情况
1. 江苏省优秀毕业生
2. 南京大学优秀博士学位论文
主要学术论文
(#Co-first author; *Corresponding author.)
1. Tingxizi Liang#, Yuxiang Dong#, Irina Cheng, Ping Wen, Fengqin Li, Feng Liu, Qing Wu, En Ren, Peifeng Liu*, Hongjun Li*, Zhen Gu*,In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy, Nature BiomedicalEngineering, 2024, 8, 1469–1482. (Cover feature)
2. Tingxizi Liang, Di Wen, Guojun Chen, Amanda Chan, Zhaowei Chen, Hongjun Li, Zejun Wang, Xiao Han, Liping Jiang*, Jun-Jie Zhu*and Zhen Gu*, Adipocyte-Derived Anticancer Lipid Droplet, Advanced Materials, 2021, 33, 2100629. (Cover feature)
3. Tingxizi Liang, Benhua Zhang, Zejing Xing, Yuxiang Dong, Hongmei Xu, Xueqin Chen, Liping Jiang, Jun-Jie Zhu, Qianhao Min*,Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size TransformableNanoframeworks, Angewandte Chemie International Edition, 2021, 60, 11464-11473.
4. Tingxizi Liang, Zhaowei Chen, Hongjun Li* and Zhen Gu*, Bioorthogonal catalysis for biomedical applications, Trends in Chemistry,2022, 4, 157-168.
5. Tingxizi Liang, Di Wen, Xintong Zhong, Liping Jiang*, Jun-Jie Zhu*, Zhen Gu*, Therapeutic potential of adipose tissue, ScienceBulletin, 2020, 65, 1702-1704.
6. Tingxizi Liang, Zejing Xing, Li-Ping Jiang, and Jun-Jie Zhu*, Tailoring Nanoparticles for Targeted Drug Delivery: from Organ toSubcellular Level, View, 2021, 2, 20200131.
7. Tingxizi Liang*, Hongjun Li* and Zhen Gu*, Anti-pneumonia natural tea nanodots, Matter, 2021, 4, 3081-3094. (Preview)
8. Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu and Zhen Gu*, Nanotechnology against diabetes, Nanotechnology, 2020,32, 012001. (As a charpter of “Roadmap on nanomedicine”).
9. Tingxizi Liang, Zhigang Yao, Jie Ding, Qianhao Min*, Liping Jiang*, and Jun-Jie Zhu, Cascaded Aptamers-Governed Multistage DrugDelivery System Based on Biodegradable Envelope-Type Nanovehicle for Targeted Therapy of HER2-Overexpressing Breast Cancer, ACS Applied Materials & Interfaces., 2018, 10, 34050-34059.
10. Jie Ding#, Tingxizi Liang#, Qianhao Min*, Liping Jiang* and Jun-Jie Zhu, “Stealth and Fully-Laden” Drug Carriers: Self-AssembledNanogels Encapsulated with Epigallocatechin Gallate and siRNA for Drug-Resistant Breast Cancer Therapy, ACS Applied Materials & Interfaces, 2018, 10, 9938-9948.
