程文黛，中国科学技术大学苏州高等研究院的博士后研究员，主要致力于微纳生物传感器领域的研究工作。长期专注于表面增强拉曼散射光谱（SERS）技术在生物传感领域的应用，包括但不限于探针设计、数据采集与处理、细胞内SERS信号的获取、细胞培养、细胞诱导凋亡以及细胞诱导分化等研究方向。具体研究内容包括开发针对生物活性分子Cr3+和H2O2的SERS探针，运用SERS技术在单细胞水平上监测活性氧（ROS）水平和PI3K/Akt信号通路，以及基于SERS和荧光技术实现单核苷酸多态性的高灵敏度原位检测。在SERS探针的设计与合成、SERS光谱的检测与分析、细胞状态的分析等方面经验丰富。
工作经历
2025/07-至今，中国科大苏州高等研究院，博后
2023/03-2025/03，之江实验室，博后
学习经历
2019/09-2022/12，华南师范大学，博士，光学专业
2016/09-2019/06，华南师范大学，硕士，光学专业
2012/09-2016/06，华中师范大学，学士，化学专业
电子邮箱
chengwd0702@ustc.edu.cn
主要科研项目
1. 国家自然科学基金面上项目，62175041，表面增强拉曼散射非相干相移数字全息三维成像研究，2022/01-2025/12，参与
2. 国家自然科学基金面上项目，61875059，壳层隔绝增强拉曼/定量相位成像用于干细胞分化状态表征研究，2019/01-2022/12，主要参与者
3. 国家重大科研仪器研制项目，61727814，数字全息/微分干涉双通道相移相位测量显微镜研制，2018/01-2022/12，参与
4. 国家自然科学基金面上项目，12374345，局域表面等离激元有序微纳结构阵列功能基元构筑及生化传感芯片应用示范研究，2024/01-2027/12，参与
主要学术论文
1. Cheng Wendai, Luo Ma, Zhang Yunshan, Ye Jing, Wan Jianhui, Zou Yingchang, Zhao Xiaoyu, Chen Zetao, Li Shuang, Zhang Diming, In situ quantitative mapping of coding single nucleotide polymorphism on mRNA inside cells by SERS-fluorescence dual-mode probe, Sensors and Actuators B: Chemical, 2024, 413:135871.
2.Cheng Wendai, Tang Ping, He Xuanmeng, Xing Xinyue, Xing Meishuang, Lu Liupeng, Ju Peng, Wang Yi, Liu Shengde, Lu Xiaoxu, and Zhong Liyun. Dynamic monitoring and quantitative characterization of intracellular H2O2 content by using SERS based boric acid nanoprobe. Talanta, 2020, 214:120863.
3. Cheng Wendai, Tang Ping, He Xuanmeng, Xing Xinyue, Liu Shengde, Zhang Feng, Lu Xiaoxu, and Zhong Liyun. Au/Ag composite-based SERS nanoprobe of Cr3+. Anal Bioanal Chem, 2021, 413(11):2951 - 2960.
4. Wan Jianhui#; Cheng Wendai#; Xing Xinyue; HeYuting; Tang Ping; Feng Yaping; Liu Shengde; Lu Xiaoxu; Zhong Liyun; A SERS-Based Dual-Parameter Monitoring Nanoprobe of ROS and PI3K/Akt during Ginsenoside Rg3-Induced Cell Apoptosis, Biosensors, 2023, 13(2).
5. Tang Ping, Cheng Wendai, He Xuanmeng, Zhang Qingnan, Zhong Jing, Lu Xiaoxu, Liu Shengde, Zhong Liyun. Raman spectrum spectral imaging revealing the molecular mechanism of Berberine-induced Jurkat cell apoptosis and the receptor-mediated Berberine delivery system. Biomed Opt Express, 2019, 10(4):1581-1600.
6. Liu Qixin, Tang Ping, Xing Xinyue, Cheng Wendai, Liu Shengde, Lu Xiaoxu, Zhong Liyun. Colorimetry/SERS dual-sensor of H2O2 constructed via TMB-Fe3O4@AuNPs. Talanta, 2022, 240, 123118.
7. Ye Jing, Liang Qi, Tan Qianglong, Chai Mengyao, Cheng Wendai, Fan Minzhi, Zhang Yunshan, Zhan Jie, Wang Yaxin, Wen Jiahong, Zhang Yongjun, Zhao Xiaoyu, Zhang Diming, A bulged-type enzyme-free recognition strategy designed for single nucleotide polymorphisms integrating with label-free electrochemical biosensor, Biosensors and Bioelectronics, 2024, 116601.
8. Zhao Yao, Tang Ping, He Xuanmeng, Xie Yue, Cheng Wendai, Xing Xinyue, Xing Meishuang, Lu Xiaoxu, Liu Shengde, Zhong Liyun. Study on the precise mechanism of Mitoxantrone-induced Jurkat cell apoptosis using surface enhanced Raman scattering. Spectrochim Acta A Mol Biomol Spectrosc, 2020, 228:117718.
9. Tang Ping, Xing Meishuang, Xing Xinyue, Tao Qiao, Cheng Wendai, Liu Shengde, Lu Xiaoxu, Zhong Liyun. Receptor-mediated photothermal/photodynamic synergistic anticancer nanodrugs with SERS tracing function. Colloids Surf B Biointerfaces, 2021, 199:111550.
10. Xing Xinyue, Zeng Yuying, Zhong Wanqing, Cheng Wendai, Zhou Chengxin, Lu Xiaoxu, Zhong Liyun. Boosting nuclear-targeted photothermal-chemotherapy by NIR-responsive hybrid membrane camouflaged nanotherapeutics. Cancer Nanotechnology, 2023, 14(1):76.
专利发明
1. 张迪鸣，程文黛.一种原位检测编码单核苷酸多态性的双模生物传感器及制备方法： CN. 202311729882.0, 已公开.
